Perglim M-2 Adverse Reactions

Hypoglycemia: As a result of the blood-sugar lowering action of glimepiride, hypoglycemia may occur, and may also be prolonged.
Eyes: Especially at the start of treatment, temporary visual impairment may occur due to the change in blood sugar levels.
Digestive Tract: Occasionally nausea, vomiting, sensations of pressure or fullness in the epigastrium, abdominal pain and diarrhea may occur, in isolated cases, liver enzyme levels may increase, and impairment of liver function (e.g. with cholestasis and jaundice), and hepatitis may develop, possibly resulting in liver failure.
Blood: Rarely thrombocytopenia and in isolated cases, leucopenia, hemolytic anemia, erythrocytopenia, granulocytopenia, agranulocytosis and pancytopenia (e.g. due to myelosuppression) may develop.
Other adverse reactions: Allergic or pseudoallergic reactions like itching, urticaria or rashes may occur. Such reactions are mild, but may become more serious and be accompanied by dyspnea, and a fall in blood pressure, sometimes progressing to shock. If urticaria occurs, a physician must be notified immediately. In isolated cases, allergic vasculitis, hypersensitivity of the skin to light, and a decrease in serum sodium may occur.